Many analgesics in group of non-steroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the COX (Cyclo-oxygenage) enzymes; responsible for producing inflammation inducing chemicals/molecules..
But inhibition of COX enzymes also inhibits some good molecules, those keep the circulation in a healthy state.
That effect may cause increase in cardiac events, after long term use; specially in a setting of previous heart disease.
NSAIDs increase risk of death in patients with prior heart attack
Even short-term use of most non-steroidal anti-inflammatory drugs (NSAIDs) in patients with prior myocardial infarction (MI) increases the risk of death and recurrent heart attack, according to a new study.
In 2007, the American Heart Association (AHA) advised doctors about the risks of NSAID use in heart patients, warning that when NSAIDs could not be avoided, they should be “limited to patients with no appropriate alternative, and only at the lowest dose for the shortest period of time.”